ENLIGHT2018

Planning details for the 2018 ENLIGHT meeting and training day, hosted by UCL.

Google Doc with latest schedule is here.

To-Do List

Chairs

• Ask Manchester/Christie what topics they would like to contribute: RA. — ✓ — Karen Kirkby responded; negotiations ongoing...
• Finalise speakers for Dosimetry session: SJ. — ✓ — Hugo Palmans invited by RA but not yet confirmed; no response from Russell Thomas.
• Invite speakers for Imaging session: GR — Currently only speakers invited by ENLIGHT committee confirmed; panel discussion and chairs need defining.
• Finalise speakers for Patient Selection session: RA — Session still needs a few more speakers, unless you want to fill it with the discussion session?
• Invite speakers for Immunotherapy session: GR — Currently only speakers invited by ENLIGHT committee confirmed; panel discussion and chairs need defining.
• Finalise speakers for Paediatrics session: RA — Session still needs a few more speakers, possibly UK, and discussion session needs defining.

• Find out whether Ran Mackay would give UK proton service talk and be willing to be an agent provocateur for one of the panel discussions: RA. — RA emailed.
• Ask vendors what sponsorship they are willing to provide and what they want in return: RA. — ✓ — Varian will provide £5k and sponsor riverboat; other vendors still TBA.
• Discuss site visit with UCLH/Bouygues: RA. — ✓ — Communications ongoing.
• Formal invitation letter (save the date letter without details, plus specific invitation to speakers): GR.
• Arrange monthly meetings with Local Organisers: GR, SJ. — Need to organise meeting soon.
• Arrange catering: SJ, Mohini Nair. — Mohini confirms this needs to be done closer to the time so we know numbers and dietary requirements.

Local Organisers

• Local point of contact: TBA...
• Industry contact: Richard Amos
• Evening entertainment: Megan Wilson
• Room bookings: Mohini Nair
• Hotel booking: TBA
• Website information: Laurent Kelleter
• Oyster cards: TBA...

Completed

• Email Manjit Dosanjh/Cai Grau about meeting dates to confirm: SJ. — ✓
• Finalise timetable for all 3 days by mid-November: All. — ✓
• Book Cruciform Building Lecture Theatre for all 4 days: SJ. — ✓ — Mohini Nair has booked Cruciform LT for 3 days, 4 cluster rooms for Monday, will book other LT for EPTN meeting.
• Identify Local Organising Committee: SJ, GR. — ✓
• Find out if we can publish contributed papers in peer-reviewed journal special edition: SJ. — ✓ (Manjit Dosanjh prefers not to publish in a journal).
• Put together web page (use HEP website) including Indico page: SJ. — ✓ — Indico page already created by CERN: they want to host the pages. We won't have edit rights.
• Check how much funding is available from CERN and Manjit Dosanjh: SJ. — ✓ — Manjit Dosanjh suggests total cost of €20–30k split 50/50 with CERN, so €15k from CERN.
• Check with Manjit Dosanjh about poster session and prizes: SJ. — ✓ — Manjit Dosanjh confirmed 23/01/18 that 1 hour session required for Wednesday afternoon for 4 talks for poster prize winners, but no actual prize. Need to organise poster boards.
• Should industrial sponsors fund lunches and evening reception? — ENLIGHT committee preferred minimal sponsorship (we are not PTCOG).
• Put together detailed list of speakers and topics for each session by 28/07/17: All. — Sessions confirmed by ENLIGHT committee.
• Email suggestions for 3 speakers for each session, then forward to ENLIGHT Committee by 31/01/18: All. — ✓
• Can we use the British Museum for reception on Monday 25^th? — ✓ — No, but UCL South Cloisters booked instead.
• Find suitable location for formal dinner on Tuesday 26^th. — ✓ — Thames riverboat booked.
• Accommodation for delegates. — ✓ — List up on CERN Indico page.
• Obtain contact details for Hakan Nystrom: SJ. — ✓ — Schedule changed so no longer needed.
• Finalise speakers for Light Ions session: SJ. — ✓ — Speakers finalised; just waiting to slip discussion session topic under the radar...

Provisional Dates: Monday 25^th–Thursday 28^th June 2018

Training Day

Monday 25^th

ENLIGHT Meeting

Tuesday 26^th–Wednesday 27^th

EPTN Meeting

Thursday 28^th

UCLH PBT Site Visit

During ENLIGHT Meeting on Tuesday

Local Organising Committee

Chairs

Richard Amos, Simon Jolly, Gary Royle.

Local Support

Kate Ricketts, Stacey Holloway, Laurent Kelleter, Anastasia Basharina-Freshville, Megan Wilson, Mohini Nair

Training Day

Clinical Proton Delivery: How to design a PBT centre

Organiser: Kate Ricketts, Stacey Holloway.

Monday 25^th June, 09.30–18.00

Location: Cruciform Lecture Theatre

• Commercial vendors: Varian (TPS software and equipment hardware)

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Training Day ENLIGHT 2018

8.30am - 9am Registration and coffee

DIDACTIC SESSION

9.00 – 9.30 am (including Q&A) Lecture 2: Clinical Oncologist – Potential of protons (Yen-Ching Chang)

9.30 – 10.30am (including Q&A) Lecture 1: Technology and infrastructure of a clinical proton therapy centre (Richard Amos)

10.30-11.00am COFFEE

Workshop 1 11.00-12:30 Design and build of UCH Proton Centre (UCLH led session, Tahir Ahmed, Paulina Zakrzewska, Bouygues)

Learning outcome: Understanding the unique requirements in terms of architecture, build and infrastructure of a clinical proton therapy centre. Learning objectives: 1. Architectural insights from UCLH experience 2. Build techniques deployed at the UCH centre, BIM modelling 3. Infrastructure requirements for a clinical centre

12:30-13:30 LUNCH

Workshop 2 13:30 – 15:15 Proton treatment planning (Varian led session, Computer Cluster room) Learning outcome: understanding the difference in planning evaluation of protons compared to x-rays Learning objectives: 1. Impact and handling of range uncertainty 2. CTV optimisation vs PTV optimisation: Robust optimisation 3. Robust evaluation: Matthew Lowe (Manchester)?

15:15 – 15:30 COFFEE

Workshop 3 15:30 - 17:15 Clinical Trials in Proton Therapy (CTRAD led session, Johnny Lee) Learning outcome: Design, implementation and assessment of proton clinical trials Learning Objectives: 1. Design and challenges of proton vs photon trials 2. Patient perspective – PPI rep of CTRAD 3. Understanding the role of quality assurance – RTTQA. Output data variance, Johnny to bring previous data. 4. Big data platforms / evaluation

17:15-17:30 Wrap up

17:30 CLOSE

To do:

• Stacey email Varian, CTRAD
• Kate email Yen, Richard and Tahir Ahmed/Paulina Zakrzewska/Bouygues
• Mohini: book lecture theatre and cluster rooms. — ✓ — Mohini Nair has booked Christopher Ingold Building G20, Cruciform Building B1.15A, Foster Court B29 and Gordon Street (25) 105 Public Clusters for 12.00–16.00 for Monday 25th.

ENLIGHT Meeting

Tuesday 26^th–Wednesday 27^th June, 09.00–18.00

Location: Cruciform Lecture Theatre

Schedule

Each session approx. 2 hours with a 1 hour discussion session scheduled for before lunch.

Tuesday 26th

09:00-09:30	—	Welcome
09:30–11:00	—	Dosimetry Session
11:00–11.30	—	Coffee
11:30–12:30	—	Imaging Session pt.1
12:30–14:30	—	Lunch / Site Visits
14:30–15:30	—	Imaging Session pt.2
15:30–16:00	—	Coffee
16:00–18:00	—	Patient Selection Session

Wednesday 27th

09:00–11:00	—	Light Ions Session (including Treatment possibilities and limitations with fixed beamlines)
11:00–11:30	—	Coffee
11:30–12:45	—	Immunotherapy Session
12:45–14:00	—	Lunch
14:00–15:00	—	Poster prize winners session.
15:00–15:30	—	Coffee
15:30–17:30	—	Paediatrics Session
17:30–18:00	—	ENLIGHT 2019 Announcement and Close

Tuesday 26th June

Location: Cruciform Lecture Theatre

09:00–09:30: Welcome

Organiser: SJ

• 9:00 - 9:10: Welcome and Introduction: Manjit Dosanjh & UCL
• 9:10 - 9:30: Ran Mackay (The Christie): Update on the UK proton service — Richard has invited - waiting to confirm

09:30–11:00: Dosimetry

Organiser: SJ

• Chairs: Giuseppe Schettino, Ana Lourenco (both confirmed)
• Hugo Palmans (MedAustron/NPL): Overview (30 mins) — Richard tentatively confirmed 10/04/18: waiting on travel arrangements...
• Simona Giordanengo (Torino): New on-line beam monitoring detectors (15 mins) — Confirmed
• Russell Thomas (NPL): NPL Dosimetry and MeMPhys (15 mins) — Simon invited 28/03/18
• Simon Jolly (UCL): Water Equivalent Range Calorimeter (15 mins) — Confirmed
• Roger Harrison (University of Newcastle): The EURADOS working group activity on dosimetry in radiotherapy (suggested) (15 mins) — Accepted but wants travel & accommodation paid...

Backups:

• Stuart Green - IPEM code of practice.
• Liverpool (Carsten Welsch/Jacinta Yap) - LHCb VELO for halo monitoring.

11.30–12.30: Imaging Session 1

Organiser: GR

• Chairs: David Hawkes, Catarina Veiga — Gary needs to confirm
• Richard Amos (UCL): Clinical overview of significance of imaging — Confirmed
• Katia Parodi (LMU): CBCT for adaptive ion beam therapy — Confirmed
• Joao Seco (HIT): Topic needed — Gary to invite?
• Hugo Bouchard (Montreal): Dual energy CT — Gary to invite?
• Christopher Kurz (LMU): Topic needed — Attendance confirmed?
• Antje Knopf (Groningen): Topic needed — Gary to invite?
• Simon Rit (Creatis, Lyon): Pre-treatment imaging? — Gary to invite?
• MRI-Linac speaker from ICR, London — Gary to invite?
• Denis Dauvergne (Grenoble): On line QC of the patient treatment — Will invite if space in schedule

Backups:

• Hsiao-Ming Lu (MGH) - good but unlikely to come without budget - State of the art from a clinical perspective.
• Andy Boston - Prompt gamma.

16:00–18:00: Patient Selection

Organiser: RA

• Chairs: Stephanie Combs, Ed Smith (Stephanie confirmed)

• Adrian Crellin (Leeds): UK overview — Richard invited - waiting to confirm
• Stephanie Combs: Topic needed — Will talk and chair?
• Karen Kirkby (Manchester): Christie patient selection inc. MALTHUS — Richard invited - waiting to confirm
• Cai Grau (Aarhus, Denmark): Selection of candidates for proton therapy in a national multidisciplinary setting - the Danish experience — Manjit confirmed

Retreatment/Re-irradiation Panel Discussion:

• Bleddyn Jones (Oxford): Clinical Radiobiology of CNS Re-treatments with Photon or Particle Therapy — Confirmed
• Juliette Thariat (Caen, Baclesse and ARCHADE): Clinical importance of re-irradiation, a trial proposal — Jacques Balosso confirmed
• Piero Fossati (MedAustron): Particle therapy as a substitute for photons, BSC or surgery ? — Will talk and chair ? if needed yes, if we have a substitute I can do just one of the two

Also:

• Holland - Dutch patient selection process.
• Bleddyn Jones
• Retreatment and clinical trials.

Wednesday 27th June

Location: Cruciform Lecture Theatre

09:00–11:00: Light Ions

Organiser: SJ

• Chairs: Stuart Green, Suzie Sheehy (both confirmed)

• Radhe Mohan (MD Anderson): Medical Physics overview (15 mins) — Richard confirmed
• Jurgen Debus (HIT): Results from HIT (20 mins) — Manjit confirmed
• Roberto Orecchia (CNAO): Results from CNAO (20 mins) — Manjit confirmed
• Emanuele Scifoni (TIFPA): Comparison of treatment plans with different light ions (20 mins) — Marco confirmed
• Maurizio Vretenar (CERN): PIMMS2 Study (15 mins) — Manjit confirmed

Panel Discussion: Treatment possibilities and limitations with fixed beamlines

Backups:

• Markus Stock/Claus Schmitzer (MedAustron) - Status of MedAustron carbon line.
• Lanzhou (expensive...).
• Someone to speak on economics of ion beams.

11:30–12:45: Proton Immunotherapy Session

Organiser: GR.

• Chair: Rikky Sharma (Gary to confirm), 1 other chair required (Gary to invite) How about Jacques Balosso? SJ: would prefer female co-chair. Rita Engenhart-Cabillic (Marburg) has been invited by Manjit
• Sergio Quesada (UCL): Immuno synergies with radiation — Gary to invite?
• Samuel Valable (Jacques Balosso): Observation of Immunological responses to different ions — Jacques confirmed
• Marco Durante (CNAO): Are particles more effective than X-rays in combined immunotherapy treatments? — Marco confirmed

More speakers needed...

15:30–17:30: Paediatric Session

Organiser: RA

• Chairs: Mark Gaze, Jenny Gains (UCLH) (both confirmed)
• Yen-Ch'ing Chang (UCLH): Paediatric patient selection — Richard confirmed
• Klaus Trott (UCL?): Biological rationale for PBT treatment, neutron dose — Gary to invite?
• David Grosshans (MD Anderson): Clinical case studies and outcomes for paediatrics — Richard confirmed.
• Sabina Vennarini (Trento): Paediatric experience at Trento — Marco confirmed

Also:

• Case studies from European centres with treatment experience.

Define Panel Discussion

17:30–18:00: ENLIGHT 2019 Announcement and Close

Organiser: SJ

• Jacques Balosso: ENLIGHT 2019 Announcement in Caen — Confirmed
• Manjit Dosanjh: ENLIGHT 2018 Close — Confirmed

EPTN Meeting

Location: AV Hill Lecture Theatre

Thursday 28^th June, 10:00–16:30